Dhasedyl, Procodin, Codipront & Dextromethorphan - Cough Medicines in Singapore

A cough is a common reflex action that helps clear your airways of mucus, foreign particles, and irritants. It is a symptom of many underlying conditions such as the common cold, flu, chest infections and even allergies. A cough can be either dry or productive, meaning that it brings up phlegm or mucus. While a mild cough is usually not a cause for concern, a persistent or severe cough should be evaluated by a doctor to determine the underlying cause and appropriate treatment.  Remember, a cough is a natural defense mechanism, so don’t suppress it completely! Make an appointment to see us to  diagnose the underlying cause of your cough!

Dhasedyl Syrup

DhasedylDhasedyl is a cough suppressant used to relieve cough, and contains active ingredients (per 5 mls)

  • Codeine Phosphate 9mg
  • Promethazine HCl 3.6mg
  • Ephedrine HCl 6mg 
Codeine is an opiate and related to morphine. It is derived from the sap of the opium poppy. It is mainly used to treat pain, diarrhoea and coughing. Its cough suppressant effects typically starts about 1/2 an hour to start working, and its effects can last for up to 4-6 hours. Side effects of codeine include vomiting, constipation, lightheadedness and drowsiness.
 

Promethazine is a first-generation antihistamine, anti-psychotic, sedative, and anti-vomiting medication used to treat allergies, insomnia, and nausea. It may also help with some symptoms associated with the common cold and upper respiratory tract infections. Promethazine is generally well tolerated. Side effects of promethazine include sleepiness and confusion.

 

Ephedrine is a medication that belongs to a class of drugs named alpha/beta adrenergic agonists. It is used to treat the symptoms of low blood pressure (hypotension) during general anesthesia. Ephedrine is included in cough syrup as it increases energy and enhances one’s mood. Common side effects of ephedrine include trouble sleeping, anxiety, headache, hallucinations, high blood pressure, fast heart rate, loss of appetite, and inability to urinate.

 

Dhasedyl is frequently prescribed by general practitioners for symptoms of cough and the common cold. The standard dose for adults is 10mls thrice daily. Patients should exercise extreme caution driving and not operate heavy machinery whilst taking Dhasedyl.

Dhasedyl DM

There is a variation of Dhasedyl labelled Dhasedyl DM. Instead of codeine, dextromethorphan (described below) is used as the active ingredient. The amount of Promethazine and Ephedrine are similar to Dhasedyl.

 

As a result, Dhasedyl DM side effects such as vomiting, constipation, lightheadness and drowsiness are less pronounced.

Procodin Syrup

Procodin is also a cough suppressant used for cough relief, and contains (per 5mls)

  • Codeine Phosphate 10mg
  • Promethazine 6.25mg 
Procodin, like Dhasedyl is also frequently prescribed by general practitioners for symptoms of cough and the common cold. The standard dose for adults is 10mls thrice daily. Patients should exercise extreme caution when driving and not operate heavy machinery whilst taking Procodin.
 

Procodin What Is The Difference Between Dhasedyl And Procodin?

Referring to the ingredients above, we note the following (at an equivalent dose):

  • Dhasedyl contains ephedrine, whereas Procodin does not
  • There is a slightly higher content of codeine phosphate in Procodin, and significantly more promethazine in Procodin.

What does this mean? At a similar dose,

  • Procodin likely has more sedative effects due to the higher amount of codeine and promethazine
  • Dhasedyl will likely have less sedative effects due to the lower amount of codeine and promethazine, as well as due to the addition of ephedrine.
However, these differences may not be clinically significant and may vary from patient to patient.
 

Codipront

CodiprontCodipront is an extended release cough suppressant, and contains the following (per tablet):

  • Codeine Phosphate 30mg
  • Phenyltoloxamine 10 mg

Phenyltoloxamine is an antihistamine with sedative and pain-relieving effects. It is frequently combined with codeine in cough medications as it increases the effectiveness of codeine as a cough suppressant; and has anti-cough properties of its own. It is particularly useful in coughs which are productive due to its moderate drying action of the upper airways. Side effects include multiple drug interactions, dizziness, drowsiness, constipation, stomach upset, blurred vision, or dryness of the mouth, nose or throat.

 

Codipront is available in a syrup or tablet form, but the tablet form is more commonly seen in Singapore. The dose of Codipront for adults is 1 tablet up to thrice daily.

 

Codipront is thought to be more effective than Dhasedyl or Procodin due to its higher codeine content; although that increases the risks of side effects associated with codeine. It as also conveniently administered as it comes in the form of a tablet.

Dextromethorphan Syrup Singapore

Dextromethorphan_singaporeDextromethorphan is also a cough suppressant, and contains the following (per 10mls):

  • Dextromethorphan 30mg

It is a cough suppressant that works by decreasing the feeling of needing to cough. Studies have shown that it appears to be less effective compared to codeine when used as a medication for cough. Adverse effects include dizziness, lightheadedness, drowsiness, nervousness, restlessness, nausea and vomiting. In patients who are taking antidepressants at the same time, it can rarely cause a condition called serotonin syndrome.

 

 

In Singapore, Dextromethorphan comes in both tablet and syrup forms. The dose of Dextromethorphan for adults is 30mg thrice daily, either in tablet or syrup form. There are also formulations of dextromethorphan available over the counter. This can be found as Robitussin DM (green box).

Frequently Asked Questions

Procodin syrup is used as a cough suppressant for patients with dry coughs. Patients with productive coughs may find expectorants such as guaiphenesin more appropriate. These are found in over-the-counter cough syrups such as Robitussin PS (blue) and Robitussin EX (red).

Procodin is a cough suppressant mainly used for a dry cough. It acts on receptors in the brain to suppress cough. Patients with productive coughs may be better off with expectorants rather than cough suppressants. Patients with chronic cough may require further evaluation before starting on cough suppressants such as Procodin.

Dhasedyl is a cough suppressant containing codeine, promethazine and ephedrine. It is generally prescribed by general practitioners for the relief of dry coughs and symptoms related to the common cold.

Dhasedyl is a cough mixture to suppress coughs, and does contain 9mg of codeine per 5mls of syrup. Codeine is used as a painkiller as well as an effective cough suppressant, and is also used in other cough preparations such as Procodin and Codipront

Young children 6 years and older can take Dhasedyl. The dose for 6-12 year old children is 2.5ml - 5ml thrice daily. As always, please check with a healthcare professional, your doctor or pharmacist regarding the appropriate dose for your child before administration. The medication should always be kept out of reach of children.

Adults can take 5-10mls of Dhasedyl up to 3-4 times per day. Children 6-12 years old can take 2.5-5 mls of Dhasedyl up to 3 times per day. Dhasedyl should not be used in children less than 6 years old. It may be taken with or without food.

Please check with your health professional / medical practictioner regarding the correct dose for you before starting Dhasedyl.

References:

Cough Medicines: Suppressants, Expectorants and More | WebMD

 

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